{"id":3940,"date":"2025-09-26T17:56:40","date_gmt":"2025-09-26T15:56:40","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3940"},"modified":"2025-09-26T17:56:40","modified_gmt":"2025-09-26T15:56:40","slug":"%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/sk\/%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact\/","title":{"rendered":"\ud83e\udec0 Hodnota IMPACT-u pri podpore vedeck\u00e9ho v\u00fdskumu: dve nov\u00e9 vedeck\u00e9 publik\u00e1cie pre IMPACT!"},"content":{"rendered":"

\ud83d\udce2 Sme hrd\u00ed na to, \u017ee sa m\u00f4\u017eeme podeli\u0165 o dve najnov\u0161ie vedeck\u00e9 publik\u00e1cie s otvoren\u00fdm pr\u00edstupom, ku ktor\u00fdm Projekt IMPACT EU<\/a> prispela k podpore prelomov\u00e9ho v\u00fdskumu arytmog\u00e9nnej kardiomyopatie (ACM).<\/p>\n

\ud83d\udd2c V preh\u013eade \u201ePokroky v modelovan\u00ed arytmog\u00e9nnej kardiomyopatie pomocou modelov zalo\u017een\u00fdch na pluripotentn\u00fdch kme\u0148ov\u00fdch bunk\u00e1ch indukovan\u00fdch \u010dlovekom\u201c sa sk\u00fama najnov\u0161\u00ed pokrok vo v\u00fdvoji modelov zalo\u017een\u00fdch na hiPSC pre ACM. Diskutuje sa o 2D aj 3D modeloch, ktor\u00e9 ukazuj\u00fa ich schopnos\u0165 replikova\u0165 k\u013e\u00fa\u010dov\u00e9 patologick\u00e9 vlastnosti a ich potenci\u00e1l odhali\u0165 mechanizmy a testova\u0165 inovat\u00edvne terapie.<\/p>\n

\ud83d\udc49 Pre\u010d\u00edtajte si cel\u00fd \u010dl\u00e1nok tu: https:\/\/www.heartrhythmjournal.com\/article\/S1547-5271(25)02753-5\/fulltext<\/p>\n

\ud83d\udc8a \u0160t\u00fadia \u201eGivinostat inhibuje in vitro diferenci\u00e1ciu srdcov\u00fdch fibroadipogenick\u00fdch prekurzorov z my\u0161ieho modelu arytmog\u00e9nnej kardiomyopatie\u201c, uverejnen\u00e1 v publik\u00e1cii Biomedicine & Farmakoterapia, ukazuje, ako liek Givinostat \u2013 inhib\u00edtor hist\u00f3novej deacetyl\u00e1zy u\u017e schv\u00e1len\u00fd na in\u00e9 ochorenia \u2013 m\u00f4\u017ee zn\u00ed\u017ei\u0165 prolifer\u00e1ciu a diferenci\u00e1ciu srdcov\u00fdch fibroadipogenick\u00fdch prekurzorov (cFAP), buniek zodpovedn\u00fdch za n\u00e1hradu fibro-tuku typick\u00fa pre ACM. Tieto zistenia otv\u00e1raj\u00fa s\u013eubn\u00e9 cesty pre bud\u00face cielen\u00e9 terapie.<\/p>\n

\ud83d\udc49 Pre\u010d\u00edtajte si cel\u00fd \u010dl\u00e1nok tu: https:\/\/doi.org\/10.1016\/j.biopha.2025.118549<\/p>\n

\ud83c\udf0d Tieto \u010dl\u00e1nky predstavuj\u00fa hmatate\u013en\u00e9 v\u00fdsledky, ktor\u00e9 Projekt IMPACT EU<\/a> prin\u00e1\u0161a do v\u00fdskumu ACM, roz\u0161iruje vedomosti a otv\u00e1ra nov\u00e9 terapeutick\u00e9 perspekt\u00edvy!<\/p>\n

Universit\u00e0 degli Studi di Padova<\/a>, Lek\u00e1rske centrum Leidenskej univerzity<\/a>, Italfarmaco<\/a><\/p>\n

Alessandra Rampazzo<\/a>, Martina Calore<\/a>, Sara Vencato<\/a>, Chiara Romanato<\/a>, Angelo Velle<\/a>, Nicola Facchinello<\/a>, Paola Braghetta<\/a>, Chiara Romualdi<\/a>, Libero Vitiello<\/a>, Simonetta Andrea Licandro<\/a>, Christian Steinkuhler<\/a>, Monica Forino<\/a>, Gianluca Fossati<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\ud83d\udce2 Sme hrd\u00ed na to, \u017ee sa m\u00f4\u017eeme podeli\u0165 o dve najnov\u0161ie vedeck\u00e9 publik\u00e1cie s otvoren\u00fdm pr\u00edstupom, ku ktor\u00fdm prispel projekt IMPACT EU, ktor\u00fd podporuje prelomov\u00fd v\u00fdskum arytmog\u00e9nnej kardiomyopatie (ACM). \ud83d\udd2c V preh\u013eade \u201ePokroky v modelovan\u00ed arytmog\u00e9nnej kardiomyopatie pomocou modelov zalo\u017een\u00fdch na pluripotentn\u00fdch kme\u0148ov\u00fdch bunk\u00e1ch indukovan\u00fdch \u010dlovekom\u201c sa sk\u00fama najnov\u0161\u00ed pokrok vo v\u00fdvoji modelov zalo\u017een\u00fdch na hiPSC pre ACM. 2D aj 3D modely\u2026<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3940","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/posts\/3940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/comments?post=3940"}],"version-history":[{"count":1,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/posts\/3940\/revisions"}],"predecessor-version":[{"id":3941,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/posts\/3940\/revisions\/3941"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/media?parent=3940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/categories?post=3940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/sk\/wp-json\/wp\/v2\/tags?post=3940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}