{"id":3940,"date":"2025-09-26T17:56:40","date_gmt":"2025-09-26T15:56:40","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3940"},"modified":"2025-09-26T17:56:40","modified_gmt":"2025-09-26T15:56:40","slug":"%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/lv\/%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact\/","title":{"rendered":"\ud83e\udec0 IMPACT v\u0113rt\u012bba zin\u0101tnisk\u0101s p\u0113tniec\u012bbas atbalst\u012b\u0161an\u0101: divas jaunas zin\u0101tniskas publik\u0101cijas IMPACT!"},"content":{"rendered":"

\ud83d\udce2 M\u0113s esam lepni dal\u012bties ar div\u0101m nesen atv\u0113rt\u0101s piek\u013cuves zin\u0101tniskaj\u0101m publik\u0101cij\u0101m, kur\u0101m IMPACT ES projekts<\/a> ir devis savu ieguld\u012bjumu, atbalstot revolucion\u0101rus p\u0113t\u012bjumus par aritmog\u0113nu kardiomiop\u0101tiju (ACM).<\/p>\n

\ud83d\udd2c P\u0101rskat\u0101 \u201cAdvances in arrhythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201d (\u201cAritmog\u0113n\u0101s kardiomiop\u0101tijas model\u0113\u0161anas sasniegumi, izmantojot cilv\u0113ka induc\u0113tus pluripotentos cilmes \u0161\u016bnu mode\u013cus\u201d) ir p\u0113t\u012bts jaun\u0101kais progress uz hiPSC balst\u012btu ACM mode\u013cu izstr\u0101d\u0113. Tiek apspriesti gan 2D, gan 3D mode\u013ci, par\u0101dot to sp\u0113ju replic\u0113t galven\u0101s patolo\u0123isk\u0101s iez\u012bmes un to potenci\u0101lu atkl\u0101t meh\u0101nismus un p\u0101rbaud\u012bt inovat\u012bvas terapijas.<\/p>\n

\ud83d\udc49 Las\u012bt pilnu rakstu \u0161eit: https:\/\/www.heartrhythmjournal.com\/article\/S1547-5271(25)02753-5\/fulltext<\/p>\n

\ud83d\udc8a P\u0113t\u012bjums \u201cGivinostat in vitro inhib\u0113 sirds fibroadipog\u0113no prekursoru diferenci\u0101ciju no aritmog\u0113n\u0101s kardiomiop\u0101tijas pe\u013cu mode\u013ca\u201d, kas public\u0113ts Biomedicine & Farmakoterapija, par\u0101da, k\u0101 z\u0101les Givinostat \u2014 histone deacetil\u0101zes inhibitors, kas jau apstiprin\u0101ts citiem st\u0101vok\u013ciem, \u2014 var samazin\u0101t sirds fibroadipog\u0113no prekursoru (cFAP) \u2014 \u0161\u016bnu, kas ir atbild\u012bgas par ACM rakstur\u012bgo fibrotauksk\u0101bju aizst\u0101\u0161anu, \u2014 prolifer\u0101ciju un diferenci\u0101ciju. \u0160ie konstat\u0113jumi paver daudzsolo\u0161as iesp\u0113jas turpm\u0101kai m\u0113r\u0137tiec\u012bgai terapijai.<\/p>\n

\ud83d\udc49 Las\u012bt pilnu rakstu \u0161eit: https:\/\/doi.org\/10.1016\/j.biopha.2025.118549<\/p>\n

\ud83c\udf0d \u0160ie raksti atspogu\u013co taust\u0101mus rezult\u0101tus, ka IMPACT ES projekts<\/a> ienes ACM p\u0113t\u012bjumos, papla\u0161ina zin\u0101\u0161anas un paver jaunas terapeitisk\u0101s perspekt\u012bvas!<\/p>\n

Universit\u00e0 degli Studi di Padova<\/a>, Leidenes Universit\u0101tes Medic\u012bnas centrs<\/a>, Italfarmako<\/a><\/p>\n

Alessandra Rampazzo<\/a>, Martina Kalore<\/a>, Sara Vencato<\/a>, Chiara Romanato<\/a>, Angelo Velle<\/a>, Nicola Facchinello<\/a>, Paola Braghetta<\/a>, Chiara Romualdi<\/a>, Libero Vitiello<\/a>, Simonetta Andrea Licandro<\/a>, Kristians \u0160teinkuhlers<\/a>, Monika Forino<\/a>, Gianluca Fossati<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\ud83d\udce2 M\u0113s esam lepni dal\u012bties ar div\u0101m nesen\u0101m atv\u0113rt\u0101s piek\u013cuves zin\u0101tniskaj\u0101m publik\u0101cij\u0101m, kur\u0101s IMPACT EU projekts ir devis ieguld\u012bjumu, atbalstot revolucion\u0101rus p\u0113t\u012bjumus par aritmog\u0113no kardiomiop\u0101tiju (ACM). \ud83d\udd2c P\u0101rskat\u0101 \u201cAdvances in arrhythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201d (\u201cAritmog\u0113n\u0101s kardiomiop\u0101tijas model\u0113\u0161anas sasniegumi, izmantojot cilv\u0113ka induc\u0113tus pluripotentos cilmes \u0161\u016bnu mode\u013cus\u201d) ir p\u0113t\u012bts jaun\u0101kais progress uz hiPSC balst\u012btu ACM mode\u013cu izstr\u0101d\u0113. Gan 2D, gan 3D mode\u013ci\u2026<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3940","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/posts\/3940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/comments?post=3940"}],"version-history":[{"count":1,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/posts\/3940\/revisions"}],"predecessor-version":[{"id":3941,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/posts\/3940\/revisions\/3941"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/media?parent=3940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/categories?post=3940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/lv\/wp-json\/wp\/v2\/tags?post=3940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}