{"id":1689,"date":"2020-03-25T10:38:51","date_gmt":"2020-03-25T10:38:51","guid":{"rendered":"http:\/\/novalab.bold-themes.com\/main-demo\/?page_id=1689"},"modified":"2026-03-09T11:12:31","modified_gmt":"2026-03-09T10:12:31","slug":"home","status":"publish","type":"page","link":"https:\/\/impact-acmproject.eu\/hu\/","title":{"rendered":"F\u0151oldal"},"content":{"rendered":"

<\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>
<\/div>
\"https:\/\/impact-acmproject.eu\/wp-content\/uploads\/2023\/11\/logo_titolo.webp\"<\/span><\/div><\/div><\/div><\/div>
<\/div>

A kardiogenomika \u00e9s a mesters\u00e9ges intelligencia tal\u00e1lkoz\u00e1sa: el\u0151rel\u00e9p\u00e9s az aritmog\u00e9n kardiomiop\u00e1tia diagn\u00f3zis\u00e1ban \u00e9s kezel\u00e9s\u00e9ben<\/span><\/span><\/h1><\/header>

A kardiogenomika \u00e9s a mesters\u00e9ges intelligencia tal\u00e1lkoz\u00e1sa: el\u0151rel\u00e9p\u00e9s az aritmog\u00e9n kardiomiop\u00e1tia diagn\u00f3zis\u00e1ban \u00e9s kezel\u00e9s\u00e9ben<\/span><\/span><\/h1><\/header>
<\/div>
A PROJEKTR\u0150L<\/span><\/span><\/a><\/div>
H\u00cdREK \u00c9S ESEM\u00c9NYEK<\/span><\/span><\/a><\/div>
KIADV\u00c1NYOK<\/span><\/span><\/a><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>
\"bt_bb_section_bottom_section_coverage_image\"<\/div><\/section>
<\/div><\/div><\/div>
<\/div>
A projektr\u0151l<\/span><\/span><\/div>
<\/div>
<\/p>\n

Az arrhythmogenic cardiomyopathia (ACM) olyan genetikai betegs\u00e9g, amely hajlamos a kamrai arrhythmi\u00e1k \u00e9s a hirtelen sz\u00edvhal\u00e1l (SCD) el\u0151fordul\u00e1s\u00e1ra, k\u00fcl\u00f6n\u00f6sen a fiatalok \u00e9s a sportol\u00f3k k\u00f6r\u00e9ben. Az ACM-et progressz\u00edv kardiomiocita-veszt\u00e9s \u00e9s fibrofatty-helyettes\u00edt\u00e9s jellemzi.<\/p>\n

Az ACM hat\u00e9kony kezel\u00e9se jelenleg nem \u00e1ll rendelkez\u00e9sre. Ez\u00e9rt a kezel\u00e9se az SCD megel\u0151z\u00e9s\u00e9re \u00e9s a betegs\u00e9g progresszi\u00f3j\u00e1nak lelass\u00edt\u00e1s\u00e1ra \u00f6sszpontos\u00edt.<\/p>\n

A projekt \u00e1tfog\u00f3 c\u00e9lja a betegekt\u0151l kapott nagym\u00e9ret\u0171 -omikai adatok kombin\u00e1l\u00e1sa a struktur\u00e1lis \u00e9s funkcion\u00e1lis elemz\u00e9sekb\u0151l sz\u00e1rmaz\u00f3 adatokkal. in vitro<\/em> \u00e9s in vivo<\/em> modellek, a genot\u00edpus\/kardi\u00e1lis fenot\u00edpus \u00f6sszef\u00fcgg\u00e9sek azonos\u00edt\u00e1sa \u00e9rdek\u00e9ben.<\/p>\n

\n<\/div>

<\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>
<\/div><\/div><\/div>
<\/div>
<\/p>\n

Ennek \u00e9rdek\u00e9ben az IMPACT mesters\u00e9ges intelligenci\u00e1n (AI) alapul\u00f3 integr\u00e1ci\u00f3t val\u00f3s\u00edt meg az ACM betegregiszterb\u0151l sz\u00e1rmaz\u00f3 klinikai \u00e9s -omikai adatokb\u00f3l, fel\u00fcgyelet n\u00e9lk\u00fcli vegyesadat-klaszterez\u00e9st \u00e9s fenomap\u00e1l\u00e1st alkalmazva a betegek kohorsz\u00e1n bel\u00fcli fenot\u00edpusos alcsoportok azonos\u00edt\u00e1s\u00e1ra, ami ter\u00e1pi\u00e1san alkalmazhat\u00f3 c\u00e9lpontok kimutat\u00e1s\u00e1hoz, valamint az ACM betegek r\u00e9tegz\u00e9s\u00e9hez vezet. A projekt relev\u00e1ns preklinikai modelleket dolgoz ki \u00e9s jellemez, nevezetesen a 3D-t. in vitro <\/em>sz\u00edv mikrosz\u00f6vetek; azt is meg fogja \u00e1llap\u00edtani, hogy hasznosak-e e betegs\u00e9gg\u00e9nek bizonytalan klinikai jelent\u0151s\u00e9ggel b\u00edr\u00f3 vari\u00e1nsainak \u00e9rtelmez\u00e9s\u00e9ben, valamint a ter\u00e1pi\u00e1san megc\u00e9lozhat\u00f3 k\u00f3ros molekul\u00e1ris \u00fatvonalak azonos\u00edt\u00e1s\u00e1ban.<\/p>\n

Munk\u00e1j\u00e1val a projekt \u00faj ter\u00e1pi\u00e1kat k\u00edv\u00e1n el\u0151k\u00e9sz\u00edteni a f\u0151bb sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek kezel\u00e9s\u00e9re.<\/p>\n

\n<\/div>

<\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/section>
<\/div><\/div><\/div>
<\/div>
A projekt partnere<\/span><\/span><\/div>
<\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div>
\"Universit\u00e0<\/a><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>
\"Consorzio<\/a><\/div><\/div><\/div><\/div>
\"Maastrichti<\/a><\/div><\/div><\/div><\/div>
\"AccelBio\"<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>
\"Italfarmaco\"<\/a><\/div><\/div><\/div><\/div>
\"UMC<\/a><\/div><\/div><\/div><\/div>
\"Lutech\"<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>
<\/div><\/div>
<\/div><\/div><\/div>
<\/span><\/div>
<\/div>

H\u00edrek \u00e9s esem\u00e9nyek<\/span><\/span><\/h2><\/header>
<\/div><\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div>
\r\n\t\t<\/div>
<\/div>