{"id":3982,"date":"2025-11-03T10:05:57","date_gmt":"2025-11-03T09:05:57","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3982"},"modified":"2025-11-03T10:05:57","modified_gmt":"2025-11-03T09:05:57","slug":"%f0%9f%ab%80-impact-in-supporting-research-on-acm-new-scientific-publication","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/fr\/%f0%9f%ab%80-impact-in-supporting-research-on-acm-new-scientific-publication\/","title":{"rendered":"\ud83e\udec0 IMPACT dans le soutien \u00e0 la recherche sur l'ACM: nouvelle publication scientifique!"},"content":{"rendered":"

\ud83e\uddec Projet IMPACT UE<\/a> en soutenant la recherche scientifique sur #ACM<\/strong>!<\/p>\n

\ud83d\udce2 Nous sommes fiers d'annoncer la publication d'une nouvelle publication scientifique en libre acc\u00e8s d\u00e9velopp\u00e9e dans le cadre de #IMPACT<\/strong>, contribuant \u00e0 la recherche de pointe sur la cardiomyopathie arythmog\u00e9nique (ACM).<\/p>\n

\ud83d\udd2c L\u2019\u00e9tude, intitul\u00e9e \u00abCaract\u00e9risation ph\u00e9notypique et transcriptomique int\u00e9gr\u00e9e de la cardiomyopathie li\u00e9e \u00e0 la desmine dans les cardiomyocytes d\u00e9riv\u00e9s du hiPSC et classification des caract\u00e9ristiques de la maladie bas\u00e9e sur l'apprentissage automatique<\/em><\/strong>\u00bb a \u00e9t\u00e9 publi\u00e9 dans #EuropeanJournalOfCellBiologie<\/strong>.<\/p>\n

\ud83e\udec0 Cette \u00e9tude propose une analyse ph\u00e9notypique, fonctionnelle et transcriptomique int\u00e9gr\u00e9e de la cardiomyopathie li\u00e9e \u00e0 la desmination caus\u00e9e par une mutation pathog\u00e8ne dans la #DES<\/strong> g\u00e8ne, en utilisant des cardiomyocytes d\u00e9riv\u00e9s de hiPSC.<\/p>\n

En combinant l'imagerie avanc\u00e9e, les mod\u00e8les de tissus cardiaques d'ing\u00e9nierie (EHT) et l'analyse bas\u00e9e sur l'apprentissage automatique, la recherche r\u00e9v\u00e8le comment la mutation perturbe la structure cellulaire, la fonction mitochondriale et la contractilit\u00e9.<\/p>\n

\ud83d\udca1 Les r\u00e9sultats d\u00e9montrent comment le ph\u00e9notypage bas\u00e9 sur l'IA et les mod\u00e8les cardiaques \u00e0 base de cellules souches peuvent faire progresser la compr\u00e9hension des cardiomyopathies arythmog\u00e8nes et desminaires, ouvrant la voie \u00e0 des diagnostics de pr\u00e9cision et \u00e0 de nouvelles strat\u00e9gies th\u00e9rapeutiques.<\/p>\n

\ud83d\udc49 Lire l'article complet ici: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0171933525000275?via%3Dihub<\/a><\/p>\n

\ud83c\udf0d Cette publication repr\u00e9sente un autre r\u00e9sultat tangible de la mission du projet IMPACT de faire progresser la compr\u00e9hension scientifique et l'innovation dans le domaine de l'ACM!<\/p>\n

#Projet IMPACT<\/strong> #EICPathfinder<\/strong> #Cardiomyopathie<\/strong> #ACM<\/strong> #hiPSC<\/strong> #MachineLearning<\/strong> #Recherche Scientifique<\/strong> #EUEIC<\/strong> #Innovation<\/strong> #Biologie cellulaire<\/strong><\/p>\n

Peter Sommer, Ph.D.<\/a>, Konstantinos G.<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\u00ab \ud83e\uddec IMPACT EU project in support scientific research on #ACM! \ud83d\udce2 Nous sommes fiers d'annoncer la publication d'une nouvelle publication scientifique en libre acc\u00e8s d\u00e9velopp\u00e9e dans le cadre de #IMPACT, contribuant \u00e0 la recherche de pointe sur la cardiomyopathie arythmog\u00e9nique (ACM). \ud83d\udd2c L\u2019\u00e9tude intitul\u00e9e \u00abIntegrated phenotypic and transcriptomic characterization of desmin-related cardiomyopathy in hiPSC-derived cardiomyocytes and\u2026\u00bb (Caract\u00e9risation ph\u00e9notypique et transcriptomique int\u00e9gr\u00e9e de la cardiomyopathie li\u00e9e \u00e0 la desmine dans les cardiomyocytes d\u00e9riv\u00e9s du hiPSC et )<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[40,39],"class_list":["post-3982","post","type-post","status-publish","format-standard","hentry","category-news","tag-open-access","tag-publication"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/comments?post=3982"}],"version-history":[{"count":2,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3982\/revisions"}],"predecessor-version":[{"id":3984,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3982\/revisions\/3984"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/media?parent=3982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/categories?post=3982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/tags?post=3982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}