{"id":3940,"date":"2025-09-26T17:56:40","date_gmt":"2025-09-26T15:56:40","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3940"},"modified":"2025-09-26T17:56:40","modified_gmt":"2025-09-26T15:56:40","slug":"%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/fr\/%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact\/","title":{"rendered":"\ud83e\udec0 La valeur d'IMPACT dans le soutien \u00e0 la recherche scientifique: deux nouvelles publications scientifiques pour IMPACT!"},"content":{"rendered":"

\ud83d\udce2 Nous sommes fiers de partager deux publications scientifiques r\u00e9centes en libre acc\u00e8s auxquelles Projet IMPACT UE<\/a> a contribu\u00e9, en soutenant la recherche r\u00e9volutionnaire sur la cardiomyopathie arythmog\u00e9nique (ACM).<\/p>\n

\ud83d\udd2c La revue \u00abAdvances in arythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u00bb (Avances dans la mod\u00e9lisation de la cardiomyopathie arythmog\u00e9nique \u00e0 l'aide de mod\u00e8les pluripotents \u00e0 base de cellules souches induits par l'homme) explore les derniers progr\u00e8s r\u00e9alis\u00e9s dans le d\u00e9veloppement de mod\u00e8les \u00e0 base de hiPSC pour la MCA. Les mod\u00e8les 2D et 3D sont discut\u00e9s, montrant leur capacit\u00e9 \u00e0 reproduire des caract\u00e9ristiques pathologiques cl\u00e9s et leur potentiel \u00e0 d\u00e9couvrir des m\u00e9canismes et \u00e0 tester des th\u00e9rapies innovantes.<\/p>\n

\ud83d\udc49 Lire l'article complet ici: https:\/\/www.heartrhythmjournal.com\/article\/S1547-5271(25)02753-5\/texte int\u00e9gral<\/p>\n

\ud83d\udc8a L\u2019\u00e9tude intitul\u00e9e \u00abGivinostat inhibits in vitro diff\u00e9renciation of cardiac fibroadipogenic pr\u00e9curseurs from a mouse model of arythmogenic cardiomyopathy\u00bb (Le givinostat inhibe la diff\u00e9renciation in vitro des pr\u00e9curseurs fibroadipog\u00e8nes cardiaques \u00e0 partir d\u2019un mod\u00e8le murin de cardiomyopathie arythmog\u00e9nique), publi\u00e9e dans Biomedicine & Pharmacotherapy, montre comment le m\u00e9dicament Givinostat \u2013 un inhibiteur de l\u2019histone d\u00e9sac\u00e9tylase d\u00e9j\u00e0 approuv\u00e9 pour d\u2019autres affections \u2013 peut r\u00e9duire la prolif\u00e9ration et la diff\u00e9renciation des pr\u00e9curseurs fibroadipog\u00e8nes cardiaques (cFAP), les cellules responsables du remplacement de la fibrograse typique de l\u2019ACM. Ces r\u00e9sultats ouvrent des pistes prometteuses pour de futures th\u00e9rapies cibl\u00e9es.<\/p>\n

\ud83d\udc49 Lire l'article complet ici: https:\/\/doi.org\/10.1016\/j.biopha.2025.118549<\/p>\n

\ud83c\udf0d Ces articles repr\u00e9sentent les r\u00e9sultats tangibles que le Projet IMPACT UE<\/a> apporte \u00e0 la recherche de l'ACM, \u00e9largit les connaissances et ouvre de nouvelles perspectives th\u00e9rapeutiques!<\/p>\n

Universit\u00e0 degli Studi di Padova<\/a>, Centre m\u00e9dical de l'universit\u00e9 de Leyde<\/a>, Italfarmaco<\/a><\/p>\n

Alessandra Rampazzo<\/a>, Martina Calore<\/a>, Sara Vencato<\/a>, Chiara Romanato<\/a>, Angelo Velle<\/a>, Nicola Facchinello<\/a>, Paola Braghetta<\/a>, Chiara Romualdi<\/a>, Libero Vitiello<\/a>, Simonetta Andrea Licandro<\/a>, Christian Steinkuhler<\/a>, Monica Forino<\/a>, Gianluca Fossati<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\ud83d\udce2 Nous sommes fiers de partager deux publications scientifiques r\u00e9centes en libre acc\u00e8s auxquelles le projet IMPACT EU a contribu\u00e9, soutenant la recherche r\u00e9volutionnaire sur la cardiomyopathie arythmog\u00e9nique (ACM). \ud83d\udd2c La revue \u00abAdvances in arythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u00bb (Avances dans la mod\u00e9lisation de la cardiomyopathie arythmog\u00e9nique \u00e0 l'aide de mod\u00e8les pluripotents \u00e0 base de cellules souches induits par l'homme) explore les derniers progr\u00e8s r\u00e9alis\u00e9s dans le d\u00e9veloppement de mod\u00e8les \u00e0 base de hiPSC pour la MCA. Mod\u00e8les 2D et 3D\u2026<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3940","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/comments?post=3940"}],"version-history":[{"count":1,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3940\/revisions"}],"predecessor-version":[{"id":3941,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/posts\/3940\/revisions\/3941"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/media?parent=3940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/categories?post=3940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/fr\/wp-json\/wp\/v2\/tags?post=3940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}