{"id":3940,"date":"2025-09-26T17:56:40","date_gmt":"2025-09-26T15:56:40","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3940"},"modified":"2025-09-26T17:56:40","modified_gmt":"2025-09-26T15:56:40","slug":"%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/et\/%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact\/","title":{"rendered":"\ud83e\udec0 IMPACTi v\u00e4\u00e4rtus teadusuuringute toetamisel: kaks uut teaduspublikatsiooni IMPACTi jaoks!"},"content":{"rendered":"

\ud83d\udce2 Oleme uhked, et jagame kahte hiljutist avatud juurdep\u00e4\u00e4suga teaduspublikatsiooni, millele IMPACT EU projekt<\/a> on andnud oma panuse, toetades murrangulisi uuringuid ar\u00fctmogeense kardiom\u00fcopaatia (ACM) kohta.<\/p>\n

\ud83d\udd2c \u00dclevaates \u201eAdvances in arrhythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201c (Ar\u00fctmogeense kardiom\u00fcopaatia modelleerimise edusammud, kasutades inimese indutseeritud pluripotentseid t\u00fcvirakkudel p\u00f5hinevaid mudeleid) uuritakse viimaseid edusamme hiPSC-p\u00f5histe ACM-mudelite v\u00e4ljat\u00f6\u00f6tamisel. Arutatakse nii 2D- kui ka 3D-mudeleid, mis n\u00e4itavad nende v\u00f5imet kopeerida peamisi patoloogilisi omadusi ja nende potentsiaali mehhanismide avastamiseks ja uuenduslike ravimeetodite katsetamiseks.<\/p>\n

\ud83d\udc49 Loe kogu artiklit siit: https:\/\/www.heartrhythmjournal.com\/article\/S1547-5271(25)02753-5\/fulltext<\/p>\n

\ud83d\udc8a Uuringus \u201eGivinostat inhibits in vitro differentiation of cardiac fibroadipogenic precursors from arrhythmogenic cardiomyopathy\u201c (Givinostaat inhibeerib s\u00fcdame fibroadipogeensete l\u00e4hteainete in vitro diferentseerumist ar\u00fctmogeense kardiom\u00fcopaatia hiiremudelist), mis avaldati v\u00e4ljaandes Biomedicine & Pharmacotherapy, n\u00e4idatakse, kuidas ravim Givinostat \u2013 histone deatset\u00fclaasi inhibiitor, mis on juba heaks kiidetud muude seisundite jaoks \u2013 v\u00f5ib v\u00e4hendada s\u00fcdame fibroadipogeensete l\u00e4hteainete (cFAPs) proliferatsiooni ja diferentseerumist. Need on rakud, mis vastutavad ACM-ile iseloomuliku fibro-rasva asenduse eest. Need leiud avavad paljut\u00f5otavaid v\u00f5imalusi tulevasteks sihip\u00e4rasteks raviviisideks.<\/p>\n

\ud83d\udc49 Loe kogu artiklit siit: https:\/\/doi.org\/10.1016\/j.biopha.2025.118549<\/p>\n

\ud83c\udf0d Need artiklid esindavad k\u00e4egakatsutavaid tulemusi, mida IMPACT EU projekt<\/a> toob ACM teadus, laiendades teadmisi ja avades uusi terapeutilisi perspektiive!<\/p>\n

Universit\u00e0 degli Studi di Padova<\/a>, Leideni \u00fclikooli meditsiinikeskus<\/a>, Italfarmaco<\/a><\/p>\n

Alessandra Rampazzo<\/a>, Martina Calore<\/a>, Sara Vencato<\/a>, Chiara Romanato<\/a>, Angelo Velle<\/a>, Nicola Facchinello<\/a>, Paola Braghetta<\/a>, Chiara Romualdi<\/a>, Libero Vitiello<\/a>, Simonetta Andrea Licandro<\/a>, Christian Steinkuhler<\/a>, Monica Forino<\/a>, Gianluca Fossati<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\ud83d\udce2 Meil on hea meel jagada kahte hiljutist avatud juurdep\u00e4\u00e4suga teaduspublikatsiooni, millele on kaasa aidanud projekt IMPACT EU, toetades murrangulisi uuringuid ar\u00fctmogeense kardiom\u00fcopaatia (ACM) kohta. \ud83d\udd2c \u00dclevaates \u201eAdvances in arrhythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201c (Ar\u00fctmogeense kardiom\u00fcopaatia modelleerimise edusammud, kasutades inimese indutseeritud pluripotentseid t\u00fcvirakkudel p\u00f5hinevaid mudeleid) uuritakse viimaseid edusamme hiPSC-p\u00f5histe ACM-mudelite v\u00e4ljat\u00f6\u00f6tamisel. Nii 2D kui ka 3D mudelid \u2026<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3940","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/posts\/3940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/comments?post=3940"}],"version-history":[{"count":1,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/posts\/3940\/revisions"}],"predecessor-version":[{"id":3941,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/posts\/3940\/revisions\/3941"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/media?parent=3940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/categories?post=3940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/et\/wp-json\/wp\/v2\/tags?post=3940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}