{"id":3982,"date":"2025-11-03T10:05:57","date_gmt":"2025-11-03T09:05:57","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3982"},"modified":"2025-11-03T10:05:57","modified_gmt":"2025-11-03T09:05:57","slug":"%f0%9f%ab%80-impact-in-supporting-research-on-acm-new-scientific-publication","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/cs\/%f0%9f%ab%80-impact-in-supporting-research-on-acm-new-scientific-publication\/","title":{"rendered":"\ud83e\udec0 IMPACT p\u0159i podpo\u0159e v\u00fdzkumu ACM: Nov\u00e1 v\u011bdeck\u00e1 publikace!"},"content":{"rendered":"

\ud83e\uddec Projekt IMPACT EU<\/a> na podporu v\u011bdeck\u00e9ho v\u00fdzkumu v oblasti #ACM<\/strong>!<\/p>\n

\ud83d\udce2 S hrdost\u00ed oznamujeme zve\u0159ejn\u011bn\u00ed nov\u00e9 v\u011bdeck\u00e9 publikace s otev\u0159en\u00fdm p\u0159\u00edstupem, kter\u00e1 byla vyvinuta v r\u00e1mci #DOPAD<\/strong>, p\u0159isp\u00edv\u00e1 k \u0161pi\u010dkov\u00e9mu v\u00fdzkumu arytmogenn\u00ed kardiomyopatie (ACM).<\/p>\n

\ud83d\udd2c Studie s n\u00e1zvem \u201eIntegrovan\u00e1 fenotypov\u00e1 a transkriptomick\u00e1 charakterizace kardiomyopatie souvisej\u00edc\u00ed s desminem u kardiomyocyt\u016f odvozen\u00fdch z hiPSC a klasifikace p\u0159\u00edznak\u016f onemocn\u011bn\u00ed zalo\u017een\u00e1 na strojov\u00e9m u\u010den\u00ed<\/em><\/strong>\u201c bylo zve\u0159ejn\u011bno v #EuropeanJournalOfCellBiologie<\/strong>.<\/p>\n

\ud83e\udec0 Tato studie nab\u00edz\u00ed integrovanou fenotypovou, funk\u010dn\u00ed a transkriptomickou anal\u00fdzu desmin-souvisej\u00edc\u00ed kardiomyopatie zp\u016fsoben\u00e9 patogenn\u00ed mutac\u00ed #DES<\/strong> gen, pomoc\u00ed kardiomyocyt\u016f odvozen\u00fdch z hiPSC.<\/p>\n

Kombinac\u00ed pokro\u010dil\u00e9ho zobrazov\u00e1n\u00ed, um\u011bl\u00fdch model\u016f srde\u010dn\u00ed tk\u00e1n\u011b (EHT) a anal\u00fdzy zalo\u017een\u00e9 na strojov\u00e9m u\u010den\u00ed v\u00fdzkum odhaluje, jak mutace naru\u0161uje bun\u011b\u010dnou strukturu, mitochondri\u00e1ln\u00ed funkci a kontraktilitu.<\/p>\n

\ud83d\udca1 V\u00fdsledky ukazuj\u00ed, jak fenotypizace \u0159\u00edzen\u00e1 um\u011blou inteligenc\u00ed a modely srdce zalo\u017een\u00e9 na kmenov\u00fdch bu\u0148k\u00e1ch mohou pokro\u010dit v pochopen\u00ed arytmogenn\u00edch a desminov\u00fdch kardiomyopati\u00ed, co\u017e p\u0159ipravuje cestu k p\u0159esn\u00e9 diagnostice a nov\u00fdm terapeutick\u00fdm strategi\u00edm.<\/p>\n

\ud83d\udc49 Cel\u00fd \u010dl\u00e1nek si m\u016f\u017eete p\u0159e\u010d\u00edst zde: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0171933525000275?via%3Dihub<\/a><\/p>\n

\ud83c\udf0d Tato publikace p\u0159edstavuje dal\u0161\u00ed hmatateln\u00fd v\u00fdsledek posl\u00e1n\u00ed projektu IMPACT podporovat v\u011bdeck\u00e9 porozum\u011bn\u00ed a inovace v oblasti ACM!<\/p>\n

#Projekt IMPACT<\/strong> #EICPathfinder<\/strong> #Kardiomyopatie<\/strong> #ACM<\/strong> #hiPSC<\/strong> #MachineLearning<\/strong> #V\u011bdeck\u00fd v\u00fdzkum<\/strong> #EUEIC<\/strong> #Inovace<\/strong> #bun\u011b\u010dn\u00e9 biologie<\/strong><\/p>\n

Peter Sommer, Ph.D. (hudebn\u00edk)<\/a>, Konstantinos G. (hudebn\u00edk)<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Projekt \ud83e\uddec IMPACT EU na podporu v\u011bdeck\u00e9ho v\u00fdzkumu v oblasti #ACM! \ud83d\udce2 S hrdost\u00ed oznamujeme zve\u0159ejn\u011bn\u00ed nov\u00e9 v\u011bdeck\u00e9 publikace s otev\u0159en\u00fdm p\u0159\u00edstupem, kter\u00e1 byla vyvinuta v r\u00e1mci #IMPACT, p\u0159isp\u00edvaj\u00edc\u00ed k \u0161pi\u010dkov\u00e9mu v\u00fdzkumu arytmogenn\u00ed kardiomyopatie (ACM). \ud83d\udd2c Studie s n\u00e1zvem \u201eIntegrated phenotypic and transcriptomic characterization of desmin-related cardiomyopathy in hiPSC-derived cardiomyocytes and\u2026\u201c (Integrovan\u00e1 fenotypov\u00e1 a transkriptomick\u00e1 charakterizace kardiomyopatie souvisej\u00edc\u00ed s desminem u kardiomyocyt\u016f odvozen\u00fdch z hiPSC a ).<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[40,39],"class_list":["post-3982","post","type-post","status-publish","format-standard","hentry","category-news","tag-open-access","tag-publication"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/comments?post=3982"}],"version-history":[{"count":2,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3982\/revisions"}],"predecessor-version":[{"id":3984,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3982\/revisions\/3984"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/media?parent=3982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/categories?post=3982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/tags?post=3982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}