{"id":3940,"date":"2025-09-26T17:56:40","date_gmt":"2025-09-26T15:56:40","guid":{"rendered":"https:\/\/impact-acmproject.eu\/?p=3940"},"modified":"2025-09-26T17:56:40","modified_gmt":"2025-09-26T15:56:40","slug":"%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact","status":"publish","type":"post","link":"https:\/\/impact-acmproject.eu\/cs\/%f0%9f%ab%80-the-value-of-impact-in-supporting-scientific-research-two-new-scientific-publications-for-impact\/","title":{"rendered":"\ud83e\udec0 Hodnota iniciativy IMPACT p\u0159i podpo\u0159e v\u011bdeck\u00e9ho v\u00fdzkumu: dv\u011b nov\u00e9 v\u011bdeck\u00e9 publikace pro IMPACT!"},"content":{"rendered":"

\ud83d\udce2 Jsme hrd\u00ed na to, \u017ee m\u016f\u017eeme sd\u00edlet dv\u011b ned\u00e1vn\u00e9 v\u011bdeck\u00e9 publikace s otev\u0159en\u00fdm p\u0159\u00edstupem, ke kter\u00fdm Projekt IMPACT EU<\/a> p\u0159isp\u00edv\u00e1 k podpo\u0159e pr\u016fkopnick\u00e9ho v\u00fdzkumu arytmogenn\u00ed kardiomyopatie (ACM).<\/p>\n

\ud83d\udd2c P\u0159ezkum \u201eAdvances in arytmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201c (Pokroky v modelov\u00e1n\u00ed arytmogenn\u00ed kardiomyopatie pomoc\u00ed lidsky indukovan\u00fdch pluripotentn\u00edch model\u016f zalo\u017een\u00fdch na kmenov\u00fdch bu\u0148k\u00e1ch) zkoum\u00e1 nejnov\u011bj\u0161\u00ed pokrok ve v\u00fdvoji model\u016f ACM zalo\u017een\u00fdch na hiPSC. Jsou diskutov\u00e1ny 2D i 3D modely, kter\u00e9 ukazuj\u00ed jejich schopnost replikovat kl\u00ed\u010dov\u00e9 patologick\u00e9 rysy a jejich potenci\u00e1l odhalit mechanismy a testovat inovativn\u00ed terapie.<\/p>\n

\ud83d\udc49 Cel\u00fd \u010dl\u00e1nek si m\u016f\u017eete p\u0159e\u010d\u00edst zde: https:\/\/www.heartrhythmjournal.com\/article\/S1547-5271(25)02753-5\/fulltext<\/p>\n

\ud83d\udc8a Studie \u201eGivinostat inhibuje in vitro diferenciaci srde\u010dn\u00edch fibroadipogenn\u00edch prekurzor\u016f z my\u0161\u00edho modelu arytmogenn\u00ed kardiomyopatie\u201c, publikovan\u00e1 v Biomedicine & Pharmacotherapy, ukazuje, jak l\u00e9k Givinostat \u2013 inhibitor histon deacetyl\u00e1zy ji\u017e schv\u00e1len\u00fd pro jin\u00e9 stavy \u2013 m\u016f\u017ee sn\u00ed\u017eit proliferaci a diferenciaci srde\u010dn\u00edch fibroadipogenn\u00edch prekurzor\u016f (cFAP), bun\u011bk odpov\u011bdn\u00fdch za fibrotukovou n\u00e1hradu typickou pro ACM. Tato zji\u0161t\u011bn\u00ed otev\u00edraj\u00ed slibn\u00e9 cesty pro budouc\u00ed c\u00edlen\u00e9 terapie.<\/p>\n

\ud83d\udc49 Cel\u00fd \u010dl\u00e1nek si m\u016f\u017eete p\u0159e\u010d\u00edst zde: https:\/\/doi.org\/10.1016\/j.biopha.2025.118549<\/p>\n

\ud83c\udf0d Tyto \u010dl\u00e1nky p\u0159edstavuj\u00ed hmatateln\u00e9 v\u00fdsledky, kter\u00e9 Projekt IMPACT EU<\/a> p\u0159in\u00e1\u0161\u00ed do v\u00fdzkumu ACM, roz\u0161i\u0159uje znalosti a otev\u00edr\u00e1 nov\u00e9 terapeutick\u00e9 perspektivy!<\/p>\n

Universit\u00e0 degli Studi di Padova<\/a>, Leiden University L\u00e9ka\u0159sk\u00e9 centrum<\/a>, Italfarmaco<\/a><\/p>\n

Alessandra Rampazzoov\u00e1<\/a>, Martina Caloreov\u00e1<\/a>, Sara Vencatoov\u00e1<\/a>, Chiara Romanato<\/a>, Angelo Velle<\/a>, Nicola Facchinellov\u00e1<\/a>, Paola Braghettaov\u00e1<\/a>, Chiara Romualdiov\u00e1<\/a>, Libero Vitiello<\/a>, Simonetta Andrea Licandro<\/a>, Christian Steinkuhler<\/a>, Monica Forinov\u00e1<\/a>, Gianluca Fossatiov\u00e1<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\ud83d\udce2 Jsme hrd\u00ed na to, \u017ee m\u016f\u017eeme sd\u00edlet dv\u011b ned\u00e1vn\u00e9 v\u011bdeck\u00e9 publikace s otev\u0159en\u00fdm p\u0159\u00edstupem, k nim\u017e p\u0159isp\u011bl projekt IMPACT EU a kter\u00e9 podporuj\u00ed pr\u016flomov\u00fd v\u00fdzkum arytmogenn\u00ed kardiomyopatie (ACM). \ud83d\udd2c P\u0159ezkum \u201eAdvances in arytmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based models\u201c (Pokroky v modelov\u00e1n\u00ed arytmogenn\u00ed kardiomyopatie pomoc\u00ed lidsky indukovan\u00fdch pluripotentn\u00edch model\u016f zalo\u017een\u00fdch na kmenov\u00fdch bu\u0148k\u00e1ch) zkoum\u00e1 nejnov\u011bj\u0161\u00ed pokrok ve v\u00fdvoji model\u016f ACM zalo\u017een\u00fdch na hiPSC. 2D i 3D modely\u2026<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3940","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/comments?post=3940"}],"version-history":[{"count":1,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3940\/revisions"}],"predecessor-version":[{"id":3941,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/posts\/3940\/revisions\/3941"}],"wp:attachment":[{"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/media?parent=3940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/categories?post=3940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/impact-acmproject.eu\/cs\/wp-json\/wp\/v2\/tags?post=3940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}