🧬 IMPACT EU project in supporting scientific research on #ACM!
📢 We are proud to announce the publication of a new scientific open access publication developed within the framework of #IMPACT, contributing to cutting-edge research on arrhythmogenic cardiomyopathy (ACM).
🔬 The study, titled “Integrated phenotypic and transcriptomic characterization of desmin-related cardiomyopathy in hiPSC-derived cardiomyocytes and machine learning-based classification of disease features” has been published in #EuropeanJournalOfCellBiology.
🫀 This study offers an integrated phenotypic, functional and transcriptomic analysis of desmin-related cardiomyopathy caused by a pathogenic mutation in the #DES gene, using hiPSC-derived cardiomyocytes.
By combining advanced imaging, engineered heart tissue (EHT) models, and machine learning-based analysis, the research reveals how the mutation disrupts cellular structure, mitochondrial function and contractility.
💡 The results demonstrate how AI-driven phenotyping and stem cell-based cardiac models can advance the understanding of arrhythmogenic and desmin-related cardiomyopathies, paving the way toward precision diagnostics and novel therapeutic strategies.
👉 Read the full article here: https://www.sciencedirect.com/science/article/pii/S0171933525000275?via%3Dihub
🌍 This publication represents another tangible result of the IMPACT project’s mission to advance scientific understanding and innovation in the field of ACM!
#IMPACTproject #EICPathfinder #Cardiomyopathy #ACM #hiPSC #MachineLearning #ScientificResearch #EUEIC #Innovation #CellBiology
